As per a cohort study, children may face improvement in the long run neurological results if they follow the immunosuppressive schedule for the small vessel central nervous system vasculitis. Among the thirteen patients who were treated with maintenance and induction therapy, only nine of them showed good results on pediatric stroke measure, as found by Susanne M. Benseler, who is the MD of Hospital for Sick Children, Toronto.
According to Neil R. Friedman from Cleveland Clinic, the condition remains badly known but reversible disorder which is not featured with clear cut treatment guidelines. The study conducted by Benseler involved 19 patients below the age of 18 years who had small vessel primary angiitis of CNS.
Two of the patients were unsuccessful in induction due to the poor maintenance of the CNS symptoms needing extra off protocol treatment. Most patients on whom the study was conducted were girls having the median age of 10. All these patients had behavioral or cognitive deficits as well and most of them further had sensori motor problems.
Proper maintenance when it comes to mycophenolate mofetil seems to be a better choice as none of the people who got it has the CCNS flare but five of them switched to drug because of flaring signs and symptoms. Due to this, researchers stopped the use of azathioprine as maintenance drug. One of the patients who achieved the regular pediatric stroke measure score had moderate score at final follow up due to the recent burst in symptoms.
At last the researchers concluded that with quality treatment, better neurologic result is a true goal of such children.