High blood pressure could be explained by a genetic “fault” which means insignificant blood vessels cannot relax, scientists mention.
US researchers affirmed that the finding could escort to a genetic test which could permit the growth of new ways of diagnosing or treating the illness.
People with high blood pressure, called hypertension, are at higher risk of having a stroke or heart attack, and can endure supplementary health problems.
Blood pressure is the power exerted by the blood against artery walls.
A variety of medications are accessible, but frequently doctors cannot decide which one is most appropriate for a patient for the reason that the fundamental cause of hypertension is unknown in 90 to 95% of cases.
Scientists do know that convinced hormones and neurotransmitters, which spread nerve impulses, send out signals which cause petite arteries known as arterioles to contract, causing blood pressure to go up.
They also help out to control blood pressure by altering the levels of electrolyte, liquid that conducts electricity, and fluid in the kidneys.
Though scientists did not know how the hormones and neurotransmitters maintained regular blood pressure when conditions altered, such as when a person unexpectedly stood up or started running.
Researchers from Washington University School of Medicine looked at mice who lacked both copies of the RGS2 gene, which is responsible for RGS2 production. They also looked at mice which only lacked one copy of the gene.
Both groups were compared to typical mice.
It was found that all the mice that lacked one or both of the genes had very high blood pressure.
The researchers say their finding that even those missing one gene were hypertensive shows the protein is crucial for controlling blood pressure. Further tests showed it was probable to treat the mice with the genetic imperfection by giving them substances which block the act of a hormone called angiotensin II, which causes arterioles to narrow, rising blood pressure.
Kendall Blumer, professor of cell biology mentioned these findings offer new insights into the cause of hypertension and how common blood pressure is regulated.
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